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Home > Traditional treatment > Adjuvant and Neoadjuvant mesothelioma's therapy


Adjuvant and Neoadjuvant mesothelioma's therapy



This treatment is applied to increase the patient's chances to cure and is applied after primary treatment procedures.

PDT (Photodynamic therapy), chemotherapy and radiation therapy are parts of adjuvant therapies. Photodynamic therapy is aimed at destroying any tumor pieces left after surgery. Photodynamic therapy is not completely accepted as a safe one due to some possible complications, despite the fact that phases I and II trials are supposed to be generally safe. It has no proven ability to keep a local control for a long time.

Usually radiation therapy or chemotherapy is applied before the surgery in order to raise the chances for success of the primary treatment.

Adjuvant Hormonal Therapy: This evaluates the combination of Nolvadex® and anti-aromatase agents or the latter alone in order to find out the best regimens of hormonal treatment applied to women having an adjuvant setting of ER-positive breast cancer.

Neoadjuvant Hormonal Therapy: Neoadjuvant therapy is held before the surgery to make the tumor smaller and make the following complicated surgical actions easier. The evaluation of anti-aromatase agents happens in the neoadjuvant setting.

New Adjuvant Chemo-radiation Therapy: The adjuvant therapy is the scheduling of extra treatment procedures after the surgery is carried out to minimize the risk of cancer recurrence. The usage of adjuvant therapy while treating all stages of gastric cancer but for IA stage during clinical trials has shown an increase of survival. The work of finding out the most suitable adjuvant therapy is carried out nowadays at clinical trials.

The name of the postoperative chemotherapy is adjuvant therapy. This treatment is applied in the following cases:

- The lymph accumulated in the nodes under the patient's arm has some breast cancer cells in it.

- The patient used to have a vast breast cancer.

- The breast cancer of the patient was too much advanced.

- The cancer cells of the patient don't give positive response to hormone receptors and are not supposed to react to the hormone therapy accordingly.

Adjuvant therapy is applied in case there is a suspicion that some cancerous cells could have split from the breast tumor and extended over the body earlier than the tumor was removed. In this situation cancerous cells can be found in any area of the patient's body. Adjuvant therapy destroys these cells minimizing the risk of cancer recurrence.

More than one drug is generally used during the chemotherapy. The Cochrane collaboration has prepared the report in 2004 where it sad that such applying of chemotherapy makes the survival higher and the risk of the cancer recurrence lower. Multi-drug chemotherapy is the most helpful for women younger than 50 but the positive effect can be seen at the patients up to 69. The contemporary knowledge doesn't allow to state how useful such treatment is for women older than 70.

Chemotherapy helps to those who still have periods in a different way. The ovaries produce oestrogen, a hormone stimulating growth of the breast cancer, that's why the chemotherapy that prevents ovaries from producing this hormone can help. This is supposed by some specialists the main reason for great success of this adjuvant treatment for women in pre-menopausal period. The negative side is that the lack of oestrogen may be the reason of early menopause that will make the woman infertile.

Still, this is not common situation. The ovaries of some women restore their functioning after they have suffered chemotherapy. This fact is quite dependant on the age of the patient, as well as on the kind of drugs applied during the chemotherapy. In case the periods do not come within a year then it unfortunately means that ovaries are unlikely to restore their functioning.

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